(R)-5-[2-[(5,6-Diethyl-2,3-dihydro-1H-inden-2-yl)amino]-1-hydroxyethyl]-8-hydroxyquinolin-2(1H)-one Maleate
(R)-5-[2-[(5,6-Diethyl-2,3-dihydro-1H-inden-2-yl)amino]-1-hydroxyethyl]-8-hydroxyquinolin-2(1H)-one Maleate
CAS: 753498-25-8
Molecular Formula: C28H32N2O7
(R)-5-[2-[(5,6-Diethyl-2,3-dihydro-1H-inden-2-yl)amino]-1-hydroxyethyl]-8-hydroxyquinolin-2(1H)-one Maleate - Names and Identifiers
(R)-5-[2-[(5,6-Diethyl-2,3-dihydro-1H-inden-2-yl)amino]-1-hydroxyethyl]-8-hydroxyquinolin-2(1H)-one Maleate - Physico-chemical Properties
| Molecular Formula | C28H32N2O7 |
| Molar Mass | 508.57 |
| Melting Point | 195-197°C (dec.) |
| Solubility | DMSO (Slightly), Methanol (Slightly) |
| Appearance | Solid |
| Color | White to Pale Beige |
| Storage Condition | Refrigerator |
| In vitro study | Indacaterol stimulates the production of gills in Chinese hamster ovary cells stably transfected with human β2 adrenoceptors. It was able to inhibit electrically induced contractions in the electrically stimulated Guinea pig trachea in a concentration-dependent manner with a pEC50 of 8.23. Indacaterol induced a concentration-dependent contractile energy effect with a maximal potency of 75% in isolated guinea pig left atria. Indacaterol concentration-dependently reverses Carbachol-induced contraction with an IC50 of 37 nM in human small airways. Indacaterol concentration-dependently reverses serotonin-induced contraction with an IC50 of 10.5 nM in rat small airways. The highest intrinsic activity of Indacaterol in rat and human small airways was 53% and 73%, respectively. Indacaterol (10 μm) produced a nearly complete inhibition of EFS-induced in vitro human bronchoconstriction, which lasted for 12 h. Indacaterol inhibits IgE-dependent histidine release from macrophages with an intrinsic activity (Emax of long-acting Indacaterol/Emax of Isoprenaline) of 1.03. Indacaterol induced the release of cAMP from human airway smooth muscle with a pEC50 of 8.53 and an Emax of 48%. Compared to CHO-K1 data in primary ASM cells, Indacaterol appears to have a reduced efficacy. |
| In vivo study | Indacaterol (6.7 μg/kg) inhibited 5-ht-induced bronchoconstriction with a maximal effect of 85% in conscious guinea pigs. Indacaterol (12.5 μg/kg) dose-dependently inhibited methacholine-induced bronchoconstriction with a maximal effect of 85% in anaesthetized large rhesus monkeys. |
(R)-5-[2-[(5,6-Diethyl-2,3-dihydro-1H-inden-2-yl)amino]-1-hydroxyethyl]-8-hydroxyquinolin-2(1H)-one Maleate - Risk and Safety
| HS Code | 29339900 |
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Spot supply
Product Name: Indacaterol Maleate Visit Supplier Webpage Request for quotationCAS: 753498-25-8
Tel: 0714-3999186
Email: 2853786052@qq.com
Mobile: 86+15671228036
QQ: 2853786052
Wechat: 15671228036
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